Among the Nasdaq 100 stocks, Analog Devices ADI and Palo Alto Networks PANW rallied 3.7% and 1.6%, respectively, making them some of the best performers at the market open. On the downside, Intel INTC and Micron Technology MU tumbled 4.1% and 3.6%, respectively.

Stocks offsetting losses in the indices on Thursday included only the United Health Group and Microsoft, which were up 1.48% and 0.21% respectively.

Stock futures are pointing to a slightly lower open for major indexes on Wednesday as investors respond to a slew of earnings reports from retailers and brace for a big speech later in the week by Federal Reserve Chair Jerome Powell.

The Dow Jones index closed slightly in positive territory. Nvidia, Palantir both sank Tuesday. A manufacturing services name sold off.

The Dow Jones Industrial Average is outpacing the other indexes on Tuesday, potentially on its way to a new record. The Dow was trading at 45,176.19, up about 0.6% on Tuesday. Part of this bump was due to the jump in shares from Home Depot.