At least two people were killed Friday after a small airplane crashed onto a busy road and collided with a bus in São Paulo, southern Brazil, injuring several others. Fire emergency services have rescued five people, Military Police Lieutenant Jefferson de Souza told CNN affiliate CNN Brasil.

The aircraft came down on the busy Marques de Sao Vicente Avenue, colliding with a bus on the ground. A passenger on the bus and a motorcyclist hit by debris were taken to hospital, while those who died were aboard the plane, fire department spokesperson Captain Maycon Cristo said.

The Cessna Caravan left Unalakleet at 2:37 p.m., and officials lost contact with it less than an hour later, according to David Olson, director of operations for Bering Air. The aircraft was 12 miles (19 kilometers) offshore, according to the U.S. Coast Guard.

The Bering Air Caravan was reported missing en route from Unalakleet to Nome with nine passengers and a pilot.