Antibiotic management of acute uncomplicated appendicitis among children was inferior to appendectomy, a randomized non-inferiority trial showed. For nearly 850 children with available primary outcome ...

Ten-year follow-up results showed that 37.8% of patients who received antibiotics versus appendectomy had a true recurrence of appendicitis. Overall, cumulative complication rates at 10 years were ...

Appendicitis. Illustration of a human appendix, showing it red and inflamed in appendicitis. The appendix is a narrow finger-shaped tube that branches off the first part of the large intestine (caecum ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

We conducted a pragmatic, nonblinded, noninferiority, randomized trial comparing antibiotic therapy (10-day course) with appendectomy in patients with appendicitis at 25 U.S. centers. The primary ...

Appendectomy alongside standard medical therapy reduced relapse rates in patients with ulcerative colitis who were in remission compared with standard medical therapy alone, a randomized superiority ...