Affinity maturation depends on how efficiently germinal centers (GCs) positively select B cells in the light zone (LZ). Positively selected GC B cells recirculate between LZs and dark zones (DZs) and ...

Greater understanding of the potential role played by B cells in autoimmune disease has spurred an interest in targeting B cells therapeutically. Greater understanding of the potential role played by ...

The authors found that Csk (a tyrosine kinase that attenuates B cell receptor signaling) is required for germinal center maintenance and efficient antibody maturation. Osaka, Japan – The immune system ...

A recent study by Vanderbilt Health researchers has revealed a greater, detrimental role for B lymphocytes (B cells) in the ...

Please provide your email address to receive an email when new articles are posted on . A “complete eradication” of B cells with chimeric antigen receptor T-cell therapy is responsible for the ...

New study demonstrates how high-affinity B cells 'bank' their best traits instead of rolling the dice and risking deleterious mutations, with implications for better vaccine design. A vaccine's ...

Our B cells help prevent us from getting sick. Their job is to make antibodies, immune system proteins that fight off viruses and other foreign invaders. And they make a lot of antibodies—thousands of ...

Sjögren's disease, a heterogeneous autoimmune disorder characterized by exocrine glandular dysfunction, has a wide spectrum of manifestations. Clinical symptoms can be difficult to characterize, and ...

For large-scale enrichment and isolation of immune cells or stem cells for cell therapy applications, common cell purification platforms separate cells based on a single surface antigen. Enrichment ...

Researchers headed by a team at Seattle Children’s Research Institute have shown for the first time that engineered human plasma B cells can be used to treat a disease—more specifically leukemia—in a ...