In a recent study published in the Microorganisms journal, researchers in China reviewed the uses of bacterial-artificial-chromosome (BAC)-based genome editing techniques in herpesvirus research.

Earlier methods to synthesize HAC relied on linking shorter DNA constructs into a larger chromosome within the cell in a process called multimerization. However, the genetic fragments tended to ...

One traditional gene-therapy method relies on homologous recombination. The desired gene segment is placed on a small plasmid and delivered by virus or liposome, but this approach has variable ...

The labs of Julian Sale and Jason Chin at the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge, U.K., have created two new tools critical for rapid genome construction at ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 40 (October 4, 2022), pp. 1-9 (9 pages) Horizontal gene transfer drives bacterial evolution. To confer ...

Bacteriophages, also called phages, are viruses that infect and kill bacteria, their natural hosts. But from a macromolecular viewpoint, phages can be viewed as nutritionally enriched packets of ...

The genome (the code of life) is not just a linear sequence of letters but it is organised in the form of folded chromosomes within the nucleus of cells. This three-dimensional organisation of the ...