Nature

Transient expression of the Bcl-2 family member, A1-a, results in nuclear localization and resistance to staurosporine-induced apoptosis

A1-a is a Bcl-2 family member found primarily in hematopoietic cells. 9 Initial studies have shown that A1-a can protect cells from undergoing apoptosis in a manner similar to Bcl-2. 34 When 32Dcl3 ...
ascopubs.org

High expression of Bcl-2 to predict poor outcome in diffuse large B-cell lymphoma patients with low international prognostic index receiving CHOP-based chemotherapy.

Primary diffuse large B-cell lymphoma of the stomach: Prognostic factors and outcomes in Indian patients. This is an ASCO Meeting Abstract from the 2015 ASCO Annual Meeting I. This abstract does not ...
ascopubs.org

Mcl-1 and bcl-2 expression in neuroendocrine carcinoma (NEC) and potential for new therapeutic target.

Use of tumor-mediated TRAIL-receptor expression to evaluate apoptotic depletion of infiltrating CD8+ immune cells in clinical colorectal cancer. SPARC microenvironment signature (SMS) in patients ...
Medical Xpress

Targeting protein BCL-2 may create a promising pathway to reversing pulmonary fibrosis

Researchers at National Jewish Health and collaborating institutions have uncovered a critical mechanism driving persistent pulmonary fibrosis and identified a promising strategy to reverse it. The ...