Cambridge, MA - Traditional bisulfite sequencing damages DNA, while enzyme-based alternatives are inconsistent. A novel methylation analysis method, called UMBS-seq, was published this week in Nature ...

Monitoring populations of tumor-macrophage fusion cells in blood prognosticates PFS and OS in pan-metastatic cancers over 2 years.

DNA methylation is a highly studied epigenetic modification that regulates genome function and plays key roles in development and disease 1. It is linked to a broad range of conditions, including ...

DNA methylation is a highly studied epigenetic modification that is involved in regulating genome function and plays fundamental roles in development and disease. 1 It is linked to a broad range of ...

5-Methylcytosine (5mC) is one of the most critical epigenetic modifications in mammals that formed by DNA methyltransferase (DNMT) through adding methyl groups to the carbon-5′position of cytosine.

This image illustrates the typical steps in next-generation sequencing (excluding single-molecule sequencing methods). The process begins with isolating genomic DNA (a) and breaking it into short ...

Detection of early-stage colorectal cancer using multiplexed extracellular vesicle proteomic biomarkers. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not ...