Cancer-associated fibroblasts (CAFs) play an important role in metastatic melanoma, and an enhanced understanding of that role could lead to important new therapeutic pathways, according to a new ...

A discovery by Mayo Clinic researchers may help explain why immunotherapy hasn't been helpful for many patients with ...

A discovery by Mayo Clinic researchers may help explain why immunotherapy hasn't been helpful for many patients with metastatic colorectal cancer. In findings published in Clinical Cancer Research, ...

Published in Clinical Cancer Research, their study identifies specific proteins, fibronectin and smooth muscle actin, in ...

Cancer-associated fibroblasts, a type of cell in the tumor, secrete a molecule called acetate. Pancreatic cancer cells use ...

nerve cells influence in particular the fibroblasts of the tumor (CAF—cancer-associated fibroblasts), which make up a large part of the tumor mass. They are also stimulated to grow and ...

Although radiotherapy is widely used in cancer treatment, its effects on the tumor microenvironment (TME) can be immunosuppressive as well as immunostimulatory. Fibroblast activation protein (FAP) is ...

Pancreatic cancer has a special relationship with the nervous system, with interactions that promote its growth. A recent study shows how tumors reprogram nerve cells for their benefit. Researchers ...

So, Santi and her colleagues at the Cancer Research UK Scotland Institute, where she previously worked as a postdoctoral researcher, investigated how their function is influenced by surrounding cells.