Remarkably, researchers soon also realized that the source of these viral oncogenes came from cellular counterparts that had been transferred by viruses from one cell to another (Varmus 1983).

In the 1980s, a promising new drug target emerged in the battle against cancer. Known as c-Myc, the protein is encoded by one of the first cellular oncogenes discovered in humans and has since been ...

Researchers at the University of California at San Francisco have identified an RNA-binding protein that increased the ...

Ten years later, it changed from an oncogene to a tumor suppressor gene ... 25 As far reaching as p53’s cellular functions appear to be, whether it is halting the cell cycle for repair, promoting ...

UC San Diego researchers have identified the molecular and cellular mechanisms that transform healthy stem cells into oral cancer at the earliest stages of the disease ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

in combination with HPV oncogenes (genes that inhibit the normal suppression of tumor growth), the researchers triggered a cascade of cellular and molecular changes that reprogrammed normal stem cells ...