Centromeres are curious structures. These specially organized chromosomal regions are best known for their unique and critical role in cell division, in which they are well understood to serve as the ...

The centromere of chromosomes plays a crucial role in cell division. Using the model plant Arabidopsis thaliana, an international team of researchers has investigated how two crucial proteins -- KNL2 ...

Meiosis, the process by which haploid products are created from diploid precursors, is central to sexual reproduction. Meiosis can be thought of as a modified mitotic division with notable ...

Centromeres are specialized chromosomal domains that direct kinetochore assembly during mitosis. CENP-A (centromere protein A), a histone H3-variant present exclusively in centromeric nucleosomes, is ...

Despite the immense amount of genetic material present in each cell, around three billion base pairs in humans, this material needs to be accurately divided in two and allocated in equal quantities.

In cells, CENP-A binds to histone H4 and HJURP before it is incorporated into the centromere. The previous model proposed that HJURP recognizes Mis18C and CENP-A is incorporated into the centromere ...

Just like you might use a belt to keep your clothes in place, the centromere holds a pair of chromatids together and attaches it to the mitotic spindle during cell division to ensure that each ...

Some scientists call it the "final frontier" of our DNA -- even though it lies at the center of every X-shaped chromosome in nearly every one of our cells. It's called the centromere, and it plays a ...

Centromeres are the chromosomal domains at which the kinetochore, a protein complex required for the correct separation of chromosomes during mitosis and meiosis, is assembled. The incorporation of ...

There is a special region in each chromosome, often found at its center: its centromere. During cell division, it ensures that new cells – from sperm and eggs to skin and neurons – end up with the ...

Super-resolution microscopy image of a mitotic chromosome (white) with the centromeres of each sister chromatid depicted in orange. Each centromere consists of two distinct chromatin subdomains ...

Researchers from the Max Planck Institute have elucidated the molecular mechanism regulating the replenishment of centromeric protein A (CENP-A) at the centromere. The study reveals how Polo-like ...