Tumors were eradicated in 30% of mice receiving cGAS LNPs injected into the tumor, in combination with immune checkpoint blockade.
Investigators from Mass General Brigham have developed a way to promote antitumor immunity by hijacking cellular machinery within cancer cells.
Data cleaning and analysis were performed using PLINK software. 53 Samples missing >2% of their genotypes were excluded because missingness can be indicative of low ...
The well-known second messenger cyclic adenosine 3′-5′-monophosphate (cAMP) plays a central role in the cells response to external stimuli. While the regulation of cAMP can be controlled by a number ...
Investigators from Mass General Brigham have developed a way to promote antitumor immunity by hijacking cellular machinery within cancer cells. The ...
William A. Frazier, Cathleen Earhart Ohlendorf, Linda Forrest Boyd, Luigi Aloe, Eugene M. Johnson, James A. Ferrendelli and Ralph A. Bradshaw ...
mBio. 2013 May 28;4(3):e00282-13. doi: 10.1128/mBio.00282-13.
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