Bugworks Research India Pvt. Ltd. has identified oxazolidinone compounds acting as DNA gyrase and DNA topoisomerase IV (Escherichia coli) inhibitors reported to be useful for the treatment of ...

DNA gyrase, a bacterial type II topoisomerase, is instrumental in maintaining DNA supercoiling during replication and transcription. Owing to its absence in higher eukaryotes, it represents an ...

DNA gyrase, a type II topoisomerase, introduces negative supercoils into DNA using ATP hydrolysis. The highly effective gyrasetargeted drugs, fluoroquinolones (FQs), interrupt gyrase by stabilizing a ...

Using high-resolution cryo-electron microscopy (cryo-em), researchers from Durham University, Jagiellonian University, and the John Innes Centre uncovered unprecedented detail of gyrase’s action on ...

Researchers reveal how DNA gyrase resolves DNA entanglements. The findings not only provide novel insights into this fundamental biological mechanism but also have potential practical applications.

Picture in your mind a traditional "landline" telephone with a coiled cord connecting the handset to the phone. The coiled telephone cord and the DNA double helix that stores the genetic material in ...

Scientists from Skoltech and MSU have investigated antibiotic nybomycin that could prove effective against bacteria resistant to other antibiotics. Their research was published in the journal ...

A sculpture that represents albicidin binding pocket, antibiotic pill and Petri dish to symbolise a threat caused by bacteria [Alina Kurokhtina] A potent plant toxin known as albicidin, which has a ...