CNO represents the most widely used chemogenetic actuator, even though it has been reported to be back-metabolized to clozapine (CLZ) in mice, rats, guinea pigs and humans 12,13,14. As CLZ is an ...

Scientists have solved the high-resolution, complex structures of drug-like compounds bound to designer brain cell receptors, paving the way for the creation of next-generation chemogenetic tools.

To both manipulate and understand this basic feature of neuronal biology, the lab of Bryan L. Roth, MD, PhD, the Michael Hooker Distinguished Professor of Pharmacology at the UNC School of Medicine, ...

Understanding of how neuronal activity modulates brain function is a key first step towards creating more effective drugs to treat a variety of neuropsychiatric illnesses, including depression, ...

In the face of the growing obesity epidemic, much research has focused on the neuronal control of feeding behavior. Agouti-related protein (AgRP) neurons express three proteins that have been ...

In order to more fully understand how diseases arise in the brain, scientists must unravel the intricate way neurons relay messages (either chemical or electrical) along a complex web of nerve cells.

Chemogenetics is a fairly new area of neuroscience that explores the use of synthetically derived receptors and selective ligands to temporarily activate or deactivate specific brain areas. These ...

Investigators at the University of Wisconsin have decreased anxiety-related behaviors in monkeys with an anxious temperament by treating them with a combination of gene therapy and low doses of the ...

While G-protein coupled receptors (GPCRs) have shown to be one of the most successful classes of druggable targets in the human genome—with estimates ranging between 30-50% of all medications ...

CHAPEL HILL, NC – Understanding of how neuronal activity modulates brain function is a key first step towards creating more effective drugs to treat a variety of neuropsychiatric illnesses, including ...