DJ-1 is a protein with wide subcellular distribution and pleiotropic functions. The loss-of-function mutations of DJ-1 are associated with autosomal recessive early-onset Parkinson's disease yet the ...

FRANKFURT. A tangle of pockets, tubes and sac-like membrane structures runs through the cells of humans, animals, plants and fungi: the endoplasmic reticulum, or ER for short. In the ER, proteins are ...

Background: Estrogen receptors (ER) and invasive protease such as urokinase-type plasminogen activator (uPA), its inhibitor plasminogen activator inhibitor type 1 (PAI-1), cathepsin D (CathD), and ...

Calcium (Ca 2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum (ER), a cellular organelle that synthesizes and transports proteins, has not ...

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these ...

Our cells are crisscrossed by a system of membrane tubes and pockets called the endoplasmic reticulum (ER). It is crucial for the production of biomolecules and is continuously built up and degraded.

Researchers describe a new way by which cells adapt to the aging process: by actively remodeling the endoplasmic reticulum, one of the cell’s largest and most complex organelles.