Scientists at the University of California, San Francisco (UCSF), have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases—from Parkinson’s ...

UCSF scientists have discovered how to target a large family of molecular switches called GTPases that are involved in myriad diseases, from Parkinson’s to cancer, and have long been thought to be ...

The Transcreener GTPase Assay Kit relies on direct detection of GDP produced by GTPases during GTP hydrolysis. The direct detection approach is a novel method to quantify activity of GTPases and their ...

Scientists at Healzen Therapeutics Co. Ltd. and Shanghai Institute of Materia Medica of the Chinese Academy of Sciences have described GTPase KRAS (G12D mutant) inhibitors reported to be useful for ...

For most of us who haven’t entirely slept through biology classes, it’s probably no secret that ATP (adenosine triphosphate) is the compound which provides the energy needed for us to move our muscles ...

Although there are more than 150 guanosine triphosphate (GTP)–binding proteins, or GTPases, only the GTPase KRas G12C has proved susceptible to small-molecule drugs. That’s because it’s tough to find ...

Astellas Pharma Inc. has described new quinazoline GTPase KRAS (G12D mutant) degradation inducers reported to be useful for the treatment of pancreatic cancer. An exemplified compound degraded ...

Scientists have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases from Parkinson's to cancer and have long been thought to be 'undruggable ...