Nuclear speckles are non–membrane-bound organelles known as storage sites for messenger RNA (mRNA) processing and splicing factors. More recently, nuclear speckles have also been implicated in ...

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its ...

Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These ...

Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the tree of life—from algae to helminths to mammals. Now, scientists have ...

Structurally, they look similar: MNK1 and MNK2 belong to the same enzyme family and are best known for regulating how cells ...

(MEMPHIS, Tenn. – December 18, 2025) Scientists at St. Jude Children’s Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows ...

A new study reveals that the twin enzymes MNK1 and MNK2 play distinct roles in the brain, with one governing memory and the other social behavior.

Consistent with their central roles in cellular function and disease pathology, kinases are well represented in the human genome. In fact, more than 500 kinases have been identified. Kinases also ...

Inhibition of the COQ8 protein could be beneficial in the treatment of diseases such as cancer. COQ8 is needed for the biosynthesis of coenzyme Q, also known as ubiquinone. A new collaborative study ...