An AI-identified lipid called P1 delivered mRNA 14.8 times more efficiently than the clinically approved lipid ALC-0315. Lipid P1's unique three-dimensional conformation allows it to bind ...

Interest in lipid nanoparticles (LNPs) as delivery vehicles for precision therapies in genetic diseases and cancers remains at an all-time high. Now, scientists from the University of Pennsylvania, ...

A review maps high throughput strategies that link automation, microfluidics, and barcoding into a unified pipeline, enabling faster, more predictive lipid nanoparticle development for genetic ...

Researchers have developed a new lipid nanoparticle design that directs mRNA to the pancreas by exploiting the organ’s own filtration barrier, a strategy that sidesteps the liver-trapping problem that ...

Imagine a scenario where a skilled hacker must upload critical software to update a central server and thwart a potentially lethal virus from wreaking havoc across a vast computer network. The ...

The most common side effects of mRNA vaccines like the COVID-19 shot are well known: soreness, mild fever and general malaise. Those symptoms, which typically resolve within days, are the natural ...

DZNE researchers have generated new insights into how the human genome shapes the chemical composition and concentration of ...