On the heels of “My Big Fat Obnoxious Fiance,” the Oxygen network and Carsey-Werner-Mandabach have partnered to produce “My Best Friend Is a Big Fat Slut,” the cabler’s first original scripted series.

NBC Universal will unveil a re-branding of the recently acquired Oxygen network at an upfront event this week. While details are still being worked out, the "Oh!" moniker that the network turned to in ...