A study has found that an ancient protein motif that binds to nucleic acids is functionally "ambidextrous." This means that the motif can interact with both natural and mirror-image nucleic acids, an ...

How did life originate? Ancient proteins may hold important clues. Every organism on Earth is made up of proteins. Although all organisms—even single-celled ones—have complex protein structures now, ...

Human MAP1LC3B (LC3B) binds proteins involved in autophagy and other cellular processes using a degenerate four-residue short linear motif known as the LC3-interacting region (LIR). Biochemical and ...

A novel study from Korea uncovers the process of synthesis and pivotal role of the transfer RNA-derived fragment, 5′-tRH-GlyGCC, in cancer progression. By interacting with splicing factors, it ...

Cellular membrane proteins play many important roles throughout the body, including transporting substances in and out of the cell, transmitting signals, speeding up reactions and helping neighboring ...

AI protein function prediction uses machine learning models trained on sequence and structural data to infer protein roles at ...

Researchers found a rare example of an ancient protein that can still function in a molecular mirror world – offering new clues about the evolutionary history of proteins that bind to nucleic acids.