aProximate TM PTCs maintain high expression of key transporters involved in drug handling, including megalin and cubilin, making them ideal for studying drug transporters and drug interactions with ...
Identifying the mechanisms of action driving a drug’s anti-cancer efficacy is critical for identifying optimal biomarkers, indications, and combinations for clinical success. Yet, systematically ...
A new study headed by teams at the Wellcome Sanger Institute, EMBL’s European Bioinformatics Institute (EMBL-EBI), and Open Targets has indicated how mutations that cause cancer drug resistance fall ...
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Neuroscientists link a common inflammatory molecule to the dopaminergic mechanisms of addiction
A new study published in the journal Science Signaling has found that an immune system protein plays a central role in the ...
Doctors have long believed the cancer drug 5-fluorouracil works by damaging the building blocks of DNA, but researchers have now found that in certain cancers, it kills cells by interfering with RNA ...
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