A discovery by Mayo Clinic researchers may help explain why immunotherapy hasn't been helpful for many patients with ...

Cancer-associated fibroblasts (CAFs) play an important role in metastatic melanoma, and an enhanced understanding of that role could lead to important new therapeutic pathways, according to a new ...

A discovery by Mayo Clinic researchers may help explain why immunotherapy hasn't been helpful for many patients with metastatic colorectal cancer. In findings published in Clinical Cancer Research, ...

Published in Clinical Cancer Research, their study identifies specific proteins, fibronectin and smooth muscle actin, in ...

nerve cells influence in particular the fibroblasts of the tumor (CAF—cancer-associated fibroblasts), which make up a large part of the tumor mass. They are also stimulated to grow and ...

Our research focuses on the tumor-permissive molecular mechanisms underlying cancer-associated fibroblast function as well as immune suppression, and how these stromal mechanisms affect cell fate and ...

Although radiotherapy is widely used in cancer treatment, its effects on the tumor microenvironment (TME) can be immunosuppressive as well as immunostimulatory. Fibroblast activation protein (FAP) is ...

So, Santi and her colleagues at the Cancer Research UK Scotland Institute, where she previously worked as a postdoctoral researcher, investigated how their function is influenced by surrounding cells.

Stromal cells, which provide structural support to breast tissue, “downregulate fibroblast marker genes and upregulate markers of senescence and cancer-associated fibroblasts.” Immune cells ...