The Bills will not have several players available to practice on Wednesday, including their starting running back.

The Buffalo Bills running back came off the field on the Bills' second possession after injuring his ankle and having it ...

The same play that sprang James Cook on a 64-yard TD last week is again setting a tone for the Bills against the Chiefs in Week 9.

Running back James Cook propelled the Buffalo Bills to a 40-9 domination of the Carolina Panthers on Sunday, rushing for a ...

During Thursday's press conference, Kansas City Chiefs defensive coordinator Steve Spagnuolo described the strategy to stop ...

James Cook rushed for 114 yards as Buffalo controlled the game and beat Kansas City 28–21. Chris Jones said the Bills “did a great job controlling tempo.” ...

Cook rushed for 114 yards on 27 carries while catching his only target for 11 yards in Sunday's 28-21 win over the Chiefs.

It appeared the Chiefs’ Kareem Hunt, who knows what a grind it is to play running back in the NFL, invited Cook to take a seat on the Chiefs bench. And Cook took up Hunt on the offer.

James Cook has delivered a standout performance for the Buffalo Bills, rushing for a career-best 216 yards and two touchdowns ...

The Buffalo Bills suffered their second consecutive loss on Monday night, falling 24-14 to the Atlanta Falcons at Mercedes-Benz Stadium. Josh Allen and the Bills offense struggled to meet their ...

The last couple seasons, it's been a theme of Buffalo Bills games. The Bills take the field for a key drive, and for whatever reason, James Cook isn't in the backfield. Maybe it's Ty Johnson. Maybe it ...

Buffalo Bills running back James Cook has seen no shortage of media coverage in 2025. Whether for his elite level of play and exploits on the field since the season started, or the offseason contract ...