Christina Applegate to Publish Memoir ‘You With the Sad Eyes' (Exclusive) ...

One person is dead following a crash that caused a car to roll several times in Des Moines County, north of Burlington.

Forecasters are tracking a potential mesoscale convective system that could unleash damaging winds, hail and possible ...

Next week, 66-year-old Joni Neidigh is competing in the National Senior Games being held in Des Moine, Iowa starting July 24.

Central Iowa residents woke up to tornado warnings Saturday morning. Find out how much rain fell and if more storms are on ...

So who will be the Democratic nominee in 2028? As the internal battle for control of that party goes on, my money is still on ...

DES MOINES, Iowa (KCCI/CNN/CNN Newsource/WKRC) — A new leukemia drug is offering hope to families. Four-year-old Madi Seivert's love for shopping is more than just child's play. Her favorite accessory ...

(Des Moines County, Iowa) One person died and another individual suffered injuries in a single-vehicle crash in Des Moines ...

The section of Park Avenue in Des Moines will be closed until Aug. 22, except to residents who need to access their homes.

The Register's Annual Great Bicycle Ride Across Iowa will travel about 15 miles through Minnesota on Monday, July 21. During ...

"I do believe Des Moines is one of the better places in the U.S. for millennials," a Kansas-born resident who's lived in the city for 11 years told Newsweek.