Challenging the long-standing belief that fibroblasts produce skin collagen, researchers have investigated collagen formation in the 'glass-skinned' amphibian axolotl and other vertebrates. They ...

A discovery by Mayo Clinic researchers may help explain why immunotherapy hasn't been helpful for many patients with ...

A discovery by Mayo Clinic researchers may help explain why immunotherapy hasn't been helpful for many patients with metastatic colorectal cancer.

Published in Clinical Cancer Research, their study identifies specific proteins, fibronectin and smooth muscle actin, in ...

Cancer-associated fibroblasts (CAFs) play an important role in metastatic melanoma, and an enhanced understanding of that role could lead to important new therapeutic pathways, according to a new ...

A discovery by Mayo Clinic researchers may help explain why immunotherapy hasn't been helpful for many patients with metastatic colorectal cancer. In findings published in Clinical Cancer Research, ...

Could aspirin keep cancer from spreading? A new study from the University of Cambridge suggests that the common pain medication could have this surprise benefit. Experts weigh in.

ER+/PR+ breast cancer, common and hormone-responsive, offers a better prognosis and is key in treatment research advancements ...

Although radiotherapy is widely used in cancer treatment, its effects on the tumor microenvironment (TME) can be immunosuppressive as well as immunostimulatory. Fibroblast activation protein (FAP) is ...

Cancer-associated fibroblasts (CAFs) are a heterogeneous population of cells with diverse origins, phenotypes, and functions, and the major component of the tumor microenvironment (TME) which play ...