This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...

AI creates anti-cancer molecules for proteins that previously could not be targeted pharmacologically by leveraging quantum ...

Preclinical analysis and clinical validation to identify biomarkers for trifluridine/tipiracil (FTD/TPI) efficacy with or without bevacizumab in patients with metastatic colorectal cancer. This is an ...

Sensitizing K-Ras G12D mutant colorectal patient-derived organoids via ferroptosis pathway. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal Cancers Symposium. This abstract does ...

There are two types of genes that are important in the development and growth of cancers: oncogenes and tumor-suppressor genes. Most often, an accumulation of mutations in both oncogenes and ...

"Colorectal cancer is the third leading cause of cancer-related deaths in the United States, and fewer than one in five people diagnosed with metastatic disease survive beyond five years after ...

The team found that without the inflammasome, the stem cells have high levels of the protein Ras, which is another oncogene product. This protein can work together with mutant Myc to drive cancer ...

The team found that without the inflammasome, the stem cells had high levels of the protein Ras, which is another oncogene product. This protein can work together with mutant Myc to drive cancer ...

KRAS, the most frequently mutated oncogene, plays a pivotal role in the initiation and progression of cancers. Oncogenic mutations in KRAS are strongly associated with tumorigenesis, occurring in ...