Computational models of the glucoregulatory system constitute a powerful tool for preclinical evaluation and mechanistic insight into therapeutics. However, in the case of diabetes, there is a dearth ...

Polymer microneedles (MNs) attract considerable attention due to their sound biocompatibility and low manufacturing cost. In this study, we prepared polypropylene (PP) MNs utilizing ultrasonic ...

Fluorescence imaging in the shortwave infrared (SWIR) window enables deeper tissue and higher-contrast visualization of pathological events compared to that in the conventional near-infrared (NIR) ...

Proteolysis-targeting chimeras (PROTACs) are an emerging class of therapeutic agents for anticancer treatments by degrading intracellular proteins via the ubiquitin-proteasome system. However, ...

Frequency upconversion provides a feasible strategy for switching the resonant wavelength of lasing modes. However, this nonlinear process requires extremely high optical properties for the medium.

Water structuring critically influences reactivity in aqueous electrocatalysis, yet the roles of interfacial water networks in electrode kinetics remain poorly defined. Here, we use the hydrogen ...

Tetrabromobisphenol A (TBBPA), a widely used brominated flame retardant, has been reported to have neurotoxicity and risks in inducing obesity. However, the underlying mechanisms remain incompletely ...

l-Serine, a nonessential amino acid in humans, possesses significant physiological functions and is widely used in the food, cosmetic, and pharmaceutical industries. Driven by steadily growing market ...

Antimicrobial peptides (AMPs) are promising alternatives to traditional antibiotics. This study uses alchemical free energy simulations to design ultrashort, cationic, broad-spectrum membrane-active ...

The asymmetric hydrogenation of substituted benzenes with oxazoline imino (pyridine) (OIP) molybdenum precatalysts is described. A comparison of the hydrogenation activities between alkylbenzenes and ...

Permethrin, a commonly used type I pyrethroid insecticide, has been shown to induce insulin resistance and adipogenesis, however the molecular mechanisms driving these effects remain unclear. This ...

Aqueous pH-neutral organic redox flow batteries are emerging as viable solutions for sustainable grid-scale energy storage. However, their advancement is hindered by the limited availability of ...