Mar 25, 2025 · Local anesthetic systemic toxicity (LAST) is a rare, life-threatening complication of receiving local anesthetic medications. LAST typically causes issues with your central nervous …

Jul 23, 2024 · This topic will discuss the pathologic pharmacology, mechanisms, and clinical presentation of toxicity, predisposing factors, and prevention and management of LAST.

However, certain co-morbidities can also increase the risk of local anesthetic overdose and, in turn, systemic toxicity. These include hepatic dysfunction, cardiac disease, pregnancy, and metabolic …

Aug 10, 2025 · For more acute poisoning with a shorter anticipated duration (e.g., local anesthetic systemic toxicity), higher doses may be reasonable for a shorter period (e.g., 500-1,000 ml infused …

Nov 1, 2020 · Local anesthetic systemic toxicity (LAST) is a rare but life-threatening complication of regional anesthesia administration. Practitioners should be prepared to respond quickly to a local …

Mar 4, 2026 · Local anesthetics are generally safe and effective when limited to the site of therapy, such as tissue infiltration, near a nerve or a plexus of nerves. However, if large amount of LA …

Sep 4, 2025 · Learn how perioperative nurses can recognize early signs of LAST and take three evidence-based steps to protect patients during local anesthesia.

Knowing how to manage these uncommon events is vital. In this review, we cover LA toxicity, its incidence, clinical features, risk factors, prevention, and management and examine i.v. lipid emulsion …

May 1, 2024 · Several of these presenting symptoms may contribute to the development of a rare complication known as local anesthetic systemic toxicity (LAST), which can affect the neurologic …

Dec 1, 2020 · Local Anesthetic Systemic Toxicity (LAST) refers to the effects, signs, and symptoms that systemic absorption of local anesthetic (LA) has on the body.