Sugar and sugar substitutes: weight control, metabolic effects, and health trade-offs | Peter Attia, M.D. This trailer is from “Ask Me Anything” episode # 74 (Ep. # 361) of The Drive which was released today (8/18/25). In the full episode, I cover: -Why sugar drives appetite and fat gain: the combined effect of low satiety, insulin spikes, and reward-system hijacking -How sugar substitutes like allulose, stevia, and erythritol stack up for weight control, glycemic impact, and gut health -The met

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