What Is PCSK9 And How Does It Affect Cholesterol? - Cardiology Community
3:58
What Is PCSK9 And How Does It Affect Cholesterol? - Cardiology Community
17 views8 months ago
YouTubeCardiology Community
PCSK9 loss-of-function variants are associated with lower LDL and lower cardiovascular risk. They are not evidence that people live 15–20 years longer, and they are not proof that a drug started later in life recreates lifelong genetic exposure. Turning “fewer CV events” into “vastly longer life” is not science.Where the post goes fully off the rails is pretending this undermines LDL/ApoB as causal in atherosclerosis. It does not. The strongest evidence base still supports ApoB-containing lipopr
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PCSK9 loss-of-function variants are associated with lower LDL and lower cardiovascular risk. They are not evidence that people live 15–20 years longer, and they are not proof that a drug started later in life recreates lifelong genetic exposure. Turning “fewer CV events” into “vastly longer life” is not science.Where the post goes fully off the rails is pretending this undermines LDL/ApoB as causal in atherosclerosis. It does not. The strongest evidence base still supports ApoB-containing lipopr
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