Personal Protective Equipment in the Perioperative Setting Perioperative personnel must wear personal protective equipment (PPE) whenever there is potential for exposure to blood, body fluids, or other infectious materials. PPE is a vital barrier that protects the skin, mucous membranes, clothing, and respiratory tract from harmful agents. The type of PPE selected should match the anticipated mode of transmission—contact, droplet, or airborne—and the nature of the patient interaction. Gloves and